A Decade in the Making.


Our science involves two revolutionary pieces of technology: Metatranscriptomic Sequencing Technology & Artificial Intelligence. 

Our metatranscriptomic sequencing technology was developed in the prestigious Los Alamos National Laboratory for national security. Viome's technology has the power to see every strain, the activity of these organisms, and whether they are producing nutrients or toxins inside the gut.

Our artificial intelligence engine runs multiple analyses of data across our massive database of information. Carefully selected high quality peer-reviewed scientific literature, expert knowledge from our team of scientists, biological testing, and customer feedback educate and train Vie – our AI machine.  Through artificial intelligence, we are able to discover what foods and supplements are ideal for the gut microbiome.

Gut Microbiome Composition

Every living organism produces RNA molecules from their DNA. By sequencing all of the RNA in the samples we receive, we can identify and quantify all of the living microorganisms in the gut (bacteria, viruses, bacteriophages, archaea, fungi, yeast, parasites, and more) at the species and strain level. The end result? A higher resolution view of your gut microbiome than has ever been available before.

Gut Microbiome Gene Expression

While identifying the microorganisms in the gut is important, we gain the most insight when we can also understand their function. This is because the microbes in the gut produce thousands of chemicals, called metabolites, that affect your overall wellness. Some of these microbial metabolites can be beneficial to our health, such as vitamin B and short chain fatty acids, while others can be detrimental, such as TMAO, which causes coronary artery disease.

By analyzing the genes that microbes express, we can identify which metabolites they produce – in other words, we can determine their role in your body’s ecosystem. By following Viome’s diet and lifestyle recommendations, a person can fine-tune the function of their gut microbiome to minimize production of harmful metabolites and maximize the production of beneficial ones.



The Viome Advantage.

What is the difference between Viome and other gut microbiome companies?


Viome is the only company whose gut microbiome test can be used to accurately make personalized diet and nutrition recommendations. The reason is our unique technology, which no other direct-to-consumer company possesses or offers. Most microbes in your gut can produce molecules that benefit you, harm you, or have no impact on your health. The only genomic tests that have the ability to see which molecules your microbes are actually producing use metatranscriptomic analysis. 

The table below compares the three most common types of gut microbiome tests.


16S Sequencing 1

Metagenomic analysis 2

Viome Metatranscriptome Sequencing

Identifies only a fraction of your gut bacteria; unable to identify nonbacterial microorganisms
Cannot identify any RNA viruses or RNA bacteriophages

Identifies all microorganisms living in your gut: bacteria, viruses, archaea, yeast, fungi, parasites and bacteriophages 3
Low resolution (mostly genus and lower resolution)
High resolution (species and strain level), but does not include RNA viruses

High resolution (species and strains) of all microorganisms
Unreliable; sequencing the same sample twice can yield very different results4
Minimal variation in results, but partially biased analysis (no RNA viruses)

Minimal variation in results and unbiased analysis
Does not measure microbe functions
Does not measure microbe functions

Quantifies the biochemical activities of all gut microorganisms
Unable to identify microbial metabolites, which are key for maintaining health
Unable to identify microbial metabolites, which are key for maintaining health

Identifies which metabolites are being produced and which are missing
Sequences DNA, which can come from food and dead microorganisms
Sequences DNA, which can come from food and dead microorganisms

Sequences RNA, which comes from live microorganisms that have a great impact on our health
Low resolution and lack of functional data preclude any actionable recommendations
Lack of functional data preclude actionable recommendations

Allows correlation of microbes and their functions with common chronic conditions, so actionable recommendations can be made

1Used by uBiome, American Gut Project and others.
2Used by uBiome (ExplorerPlus kit), DayTwo and others.
3We now understand that many common chronic diseases are associated with the presence of non-bacterial species in the gut.
4After sending duplicate stool samples to American Gut and uBiome, a journalist found that her results from the two companies were completely different.

How can Viome's metatranscriptome technology improve wellness?

  • Increase microbial species associated with overall wellness
  • Minimize microbial species associated with poor health
  • Increase the diversity of your microbiome
  • Stimulate production of beneficial metabolites
  • Minimize production of metabolites associated with poor health
  • Identify prebiotics that can induce growth of beneficial microbes and metabolites
  • Identify the ideal ratio of proteins, carbohydrates and fats for your diet
  • Identify foods that are most compatible with your metabolism
  • Recommend a diet to help you achieve and maintain a healthy weight
  • Recommend a diet that will increase your energy, focus and well-being
  • Optimize your digestion and absorption
  • Introduce beneficial (but missing) bacteria with probiotics

The Science Behind Viome

Recent research has demonstrated the microbiome’s significant role in human health and disease.
 Findings from peer-reviewed scientific articles like these have helped make Viome possible.

Obesity

Obesity, metabolic syndrome and gastrointestinal disease are all influenced by our gut microbiome.

Chervonsky

Microbiota and Autoimmunity

Cold Spring Harbor Perspectives in Biology (2013)

Autoimmune Disease

Our microbiome controls our immune system more than we realize.

Chervonsky

Microbiota and Autoimmunity

Cold Spring Harbor Perspectives in Biology (2013)

Diet

What we eat alters our microbiome faster than expected.

Diabetes

Our microbiome is associated with both type II diabetes and the complications that come with it.

Mental Health

Our gut microbiome has been shown to influence depression, cognition, behavior, and neural development.

Parkinson’s Disease

Gut microbiota have been linked to Parkinson’s disease and its motor symptoms.

Heart Disease

Certain bacteria have been linked to atherosclerosis, an all-too-common heart condition.

Alzheimer’s Disease

Microbes are involved in the development of Alzheimer’s pathology.

Colorectal Cancer

Shifts in the makeup of our gut microbiome are associated with colorectal cancer.

Want to find out why gut health is so important?

We created a simple guide to the microbiome so you can learn how to fix your gut forever.