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The Science
Behind Viome

Meet your invisible army. In the ongoing fight against chronic disease, scientists have begun to turn to an army of unexpected allies – bacteria and other microorganisms.

New technologies used by microbiologists to study tiny organisms – bacteria, viruses, archaea, fungi and more – have quietly ushered in a new era of medicine and a new understanding of the forces at work within our bodies.

Mi·cro·bi·ome

/,mīkrō’bīōm/

A person’s microbiome is the entire collection of microbes living in and on the body. The microbiome forms a living layer over your skin and parts of the inside of your body, including the lungs and the digestive tract, from the mouth all the way down to the colon.

When the microbes in your gut are out of balance, your body can't absorb nutrients the way it should. The result of this is inflammation, the root of almost every chronic disease.

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Your recommendations are backed by science and unique to you.

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Metatranscriptomic Sequencing Technology

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Artificial Intelligence

Viome's Metatranscriptomic Sequencing Technology

Viome’s technology captures everything that is happening in the gut microbiome – the key word here is happening.

Our metatranscriptomic sequencing technology was developed in the prestigious Los Alamos National Laboratory for national security. Viome is the only test on the market with the power to see every strain, the activity of these organisms, and whether they are producing nutrients or toxins. It took 15 years to sequence the human genome. We are now sequencing AND analyzing your gut microbiome – which includes identifying trillions of active microbes, and their pathways, and functions – in just a few weeks!

More on Gut Microbiome Biochemistry

Every living organism produces RNA molecules from their DNA. By sequencing all of the RNA in the samples we receive, we can identify and quantify all of the living microorganisms in the gut (bacteria, viruses, bacteriophages, archaea, fungi, yeast, parasites, and more) at the species and strain level. The end result? A higher resolution view of your gut microbiome than has ever been available before.

While identifying the microorganisms in the gut is important, we gain the most insight when we can also understand their function. To maintain health, our bodies require many biochemicals produced by the gut microbiome. Some well-known examples are vitamin K, B vitamins, and short-chain fatty acids (for example butyrate). The microbes can also produce harmful biochemicals, such as LPS. Many microbes are capable of making both good and bad biochemicals. The biochemical output depends on the food we eat and the interactions among the hundreds of species of microorganisms.

By analyzing the genes that microbes express, we can identify which metabolites they produce – in other words, we can determine their role in your body’s ecosystem. By following Viome’s diet and lifestyle recommendations, a person can fine-tune the function of their gut microbiome to minimize production of harmful metabolites and maximize the production of beneficial ones.

Here are some of the amazing things we can see with metatranscriptomic technology:

If your microbiome is not able to process nutrients in foods like spinach, beets, and almonds.

If you’re not able to digest the amount of protein you are eating.

If some of those healthy antioxidants you’re eating aren’t really benefiting you.

If you’re eating too much iron and promoting the growth of potential pathogens like Shigella and Salmonella.

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Viome’s Artificial Intelligence

Through artificial intelligence, we are able to discover what foods and supplements are ideal for you and your gut microbiome – so you can experience optimal health.

Our artificial intelligence engine runs multiple analyses of your data across our massive database of information. Carefully selected high-quality peer-reviewed scientific literature, expert knowledge from our team of scientists, biological testing, and customer feedback educate and train Vie – our AI machine.

More on Viome’s Artificial Intelligence

Our artificial intelligence engine runs multiple analyses of your data across our massive database of information. Carefully selected high quality peer-reviewed scientific literature, expert knowledge from our team of scientists, biological testing, and customer feedback educate and train Vie – our AI machine.

We meticulously collect this information and use it to educate Vie – this is called knowledge representation and machine learning in the world of AI. Vie helps us sort through mountains of data to find correlations among microorganisms, their functions, and external issues that people face. With the help of Vie we can understand your microbiome tests with greater accuracy and speed. Vie is able to algorithmically process massive data sets and discover patterns through statistics, decision analytics, logic, and other mathematical techniques.

This process is an ongoing loop where we train Vie and incorporate the resulting outcomes to our ongoing improvements and discovery, constantly refining every step of the way.

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What is the difference between Viome and other gut microbiome companies?

The table below compares Viome's technology with the technology most commonly used by other microbiome testing companies today.

16S Sequencing

Identifies only a fraction of your gut bacteria; unable to identify nonbacterial microorganisms

Sequences DNA, which can come from food and dead microorganisms

Low resolution (mostly genus and lower resolution)

Unreliable; sequencing the same sample twice can yield very different results

Does not measure microbial gene functions

Does not assess what the microbes are doing

Low resolution and lack of gene expression data preclude actionable recommendations

Metagenomic Analysis

Cannot identify any RNA viruses or RNA bacteriophages

Sequences DNA, which can come from food and dead microorganisms

High resolution (species and strain level), but does not include RNA viruses

Minimal variation in results, but partially biased analysis (no RNA viruses)

Does not measure microbial gene functions

Does not assess what the microbes are doing

Lack of gene expression data preclude actionable recommendations

Viome Metatranscriptome Sequencing

Identifies all microorganisms living in your gut: bacteria, viruses, archaea, yeast, fungi, parasites and bacteriophages

Sequences RNA, which comes from live microorganisms that have a great impact on our health

High resolution (species and strain level) of all microorganisms

Minimal variation in results and unbiased analysis

Quantifies expression levels of active microbial gene functions

Allows assessment of pathway activities that can lead to personalized health insights and recommendations with molecular-level precision based on what the microbes are doing

Gut Intelligence

Feel the difference.

Order Viome's Gut Intelligence test kit today and have it delivered right to your home! Have questions? Reach out to us at info@viome.com