What is the gut microbiome, and why does it matter?
There are approximately 40 trillion microorganisms living in your gut. They help you digest your food, produce beneficial and harmful chemicals, control infections by pathogens, regulate your immune system, and even control your emotions (ever have a gut feeling?).
These microorganisms – which make up your gut microbiome – have been implicated in maintaining optimal health, as well as many chronic conditions, including diabetes, obesity, Alzheimer’s, Parkinson’s, coronary artery disease, psoriasis, lupus, and autism. By taking care of your 40 trillion microbe friends, you can maximize your wellness and potentially prevent disease.
Gut Microbiome Composition
Every living organism produces RNA molecules from their DNA. By sequencing all of the RNA in your stool, we can identify and quantify all of the living microorganisms in your gut (bacteria, viruses, bacteriophages, archaea, fungi, yeast, parasites, and more) at the species and strain level. The end result? A higher resolution view of your gut microbiome than has ever been available before.
Every person is biochemically unique. As a result, you process macronutrients – fats, protein and carbohydrates – differently than others do.
We measure your body’s response to a nutritional challenge to determine how quickly you regain your balance and how you metabolize different macronutrients. When we combine the results of this test with your Gut Intelligence™️ test results, we can provide your ideal macronutrient ratio and make dietary recommendations that are unique to you.
Gut Microbiome Gene Expression
While identifying the microorganisms in your gut is important, we gain the most insight when we can also understand their function. This is because the microbes in your gut produce thousands of chemicals, called metabolites, that affect your overall wellness. Some of these microbial metabolites can be beneficial to our health, such as vitamin B and short chain fatty acids, while others can be detrimental, such as TMAO, which causes coronary artery disease.
By analyzing the genes that your microbes express, we can identify which metabolites they produce – in other words, we can determine their role in your body’s ecosystem. By following Viome’s diet and lifestyle recommendations, you’ll be able to fine-tune the function of your gut microbiome to minimize production of harmful metabolites and maximize the production of beneficial ones.
Not your average microbiome sequencing:
The Viome difference
Viome Metatranscriptome Sequencing
|Identifies only a fraction of your gut bacteria; unable to identify nonbacterial microorganisms||Identifies all bacteria and all other living organisms in your gut: viruses, archaea, yeast, fungi, parasites, and bacteriophages 2|
|Low resolution (genus level only)||High resolution (species & strain level)|
|Does not determine microbe function||Quantifies the biochemical activities of all gut microorganisms|
|Unreliable; sequencing the same sample twice can yield very different results3||Unbiased analysis, minimized variation in results|
|Unable to identify microbial metabolites, which are key for maintaining health||Identifies which metabolites are being produced and which are missing|
|Low resolution and lack of functional data preclude any actionable recommendations||Allows correlation of microbes and their functions with common chronic conditions, so actionable recommendations can be made|
1 Used by uBiome, American Gut Project and others.
2 We now understand that many common chronic diseases are associated with the presence of non-bacterial species in the gut.
3 After sending duplicate stool samples to American Gut and uBiome, a journalist found that her results from the two companies were completely different:
How can the Gut Metatranscriptome & Metabolic IntelligenceTM technology improve your wellness?
- Increase microbial species associated with overall wellness
- Minimize microbial species associated with poor health
- Increase the diversity of your microbiome
- Stimulate production of beneficial metabolites
- Minimize production of metabolites associated with poor health
- Identify prebiotics that can induce growth of beneficial microbes and metabolites
- Identify the ideal ratio of proteins, carbohydrates and fats for your diet
- Identify foods that are most compatible with your metabolism
- Recommend a diet to help you achieve and maintain a healthy weight
- Recommend a diet that will increase your energy, focus and well-being
- Optimize your digestion and absorption
- Introduce beneficial (but missing) bacteria with probiotics
Science behind Viome
Recent research has demonstrated the microbiome’s significant role in human health and disease.
Findings from peer-reviewed scientific articles like these have helped make Viome possible.
What we eat alters our microbiome faster than expected.
Our microbiome is associated with both type II diabetes and the complications that come with it.
Food Science and Human Wellness (2013)
Our gut microbiome has been shown to influence depression, cognition, behavior, and neural development.
Molecular Psychiatry (2016)
Gut microbiota have been linked to Parkinson’s disease and its motor symptoms.
Movement Disorders (2015)
Certain bacteria have been linked to atherosclerosis, an all-too-common heart condition.
Nature Communications (2012)
Microbes are involved in the development of Alzheimer’s pathology.
Shifts in the makeup of our gut microbiome are associated with colorectal cancer.