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      Woman smiling, supported by a healthy gut foundation

      Advanced TriSynbiotic™

      A healthy gut doesn't run on one fix. It runs on a foundation.

      Shop Now→
      Advanced TriSynbiotic™ product

      Reset your gut

      Starting at$69
      Save up to 30%
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      A million microbiomes taught us one thing:

      Almost every gut needs the same few fundamentals working together. So we built all five into one daily capsule — a postbiotic, three probiotics, and butyrate delivered direct, each one engineered to reach where it works.

      Advanced TriSynbiotic™ is the foundation we'd put under any gut — one capsule a day, built from what the data showed.
      Microscopic view of probiotic bacteria

      Most supplements guess.
      We have the data.

      Most gut supplements start with general assumptions about what tends to work. We started with what sequencing over a million microbiomes actually revealed, then let that decide what goes in the formula, and what doesn't.

      Every ingredient is clinically studied and earned its place. Nothing is here by default.

      Your gut is one of a kind.
      Its foundation isn't.

      Others bet on a single hero strain to shift your whole system. The data points elsewhere. Almost every gut benefits from the same few fundamentals working together, and when they're in place, everything else has somewhere solid to build from. Advanced TriSynbiotic™ supports all three, every day.

      • Strong gut liningStrong gut lining
      • Steady butyrate supplySteady butyrate supply
      • Balanced good bacteriaBalanced good bacteria
      product-main.webpbox-back.webpAdvnaced TriSynbiotic Gut Lining Supplment Packaginglifestyle-2.webplifestyle-3.webp

      30 CAPSULES | 1-MONTH SUPPLY

      Advanced TriSynbiotic™

      A Daily Foundation for a Stronger Gut Lining

      A once-daily 5-in-1 capsule that supports the gut foundation everything else runs on. Built from over a million sequenced microbiomes, Advanced TriSynbiotic™ combines a postbiotic, three targeted probiotics, and direct butyrate delivery to support digestion, metabolism, and appetite. Engineered to reach where they actually work.*

      • 5-in-1 Formula
      • DUOCAP® Delivery
      • GLP-1 Compatible
      Choose a pack size

      Support across three areas that matter.

      Support across three areas that matter.

      1

      A stronger gut foundation*

      A stronger gut foundation*

      Supports your gut lining and a balanced, resilient mix of good bacteria, so digestion stays comfortable and your gut bounces back from everyday ups and downs.*

      Supports your gut lining and a balanced, resilient mix of good bacteria, so digestion stays comfortable and your gut bounces back from everyday ups and downs.*

      2

      Metabolic and blood sugar balance support*

      Metabolic and blood sugar balance support*

      Supports healthy glucose metabolism and blood sugar already within the normal range, the everyday balance your energy depends on.*

      Supports healthy glucose metabolism and blood sugar already within the normal range, the everyday balance your energy depends on.*

      3

      Appetite support*

      Appetite support*

      Supports a healthy appetite and complements a GLP-1 diet and lifestyle.*

      Supports a healthy appetite and complements a GLP-1 diet and lifestyle.*

      A healthy gut supports the rest of you.

      The gut doesn't work alone. It talks to your immune system and your brain every day, and Advanced TriSynbiotic™ was built to support that whole conversation.*

      Immune support*

      Supports a healthy immune response and helps reinforce the tight junctions in your gut lining that support a healthy immune system.*

      Mood, stress, and sleep*

      Lp815 produces GABA over time to support a calm mood, a healthy stress response, and better sleep quality.*

      Focus and mental clarity*

      Through the gut-brain axis, the same ingredients that fuel your gut also support focus and everyday mental clarity.*

      Akkermansia

      A postbiotic, not a gamble.

      Akkermansia is everywhere right now, and almost always used live. That means it has to survive your stomach and settle in before it can do anything. A lot of it never makes the trip.*

      We took the more reliable route. Advanced TriSynbiotic™ uses a postbiotic form of Akkermansia, ready to work the moment it arrives, no survival required. You get the benefit Akkermansia is known for, a stronger gut lining, without leaving it to chance.*

      Live strains have to survive. A postbiotic doesn't. A more dependable way to support your gut lining.*

      More butyrate for a better-protected gut lining.

      Butyrate is the fuel your gut lining runs on. When it runs low, your gut has less to work with. Most products hope your body makes enough on its own. We don't leave it to hope. We do both:*

      Butyrate-producing bacteria are sometimes called the "sentinels of the gut." They help keep unwanted microbes from taking hold and help keep your gut environment calm and balanced.*

      1

      Make more

      A targeted butyrate-producing strain, Anaerobutyricum soehngenii, turns fiber into butyrate, building a steady supply over time.*

      2

      Deliver it direct

      CoreBiome® Tributyrin sends butyrate straight where it's needed, so your gut is supported right away.*

      3

      Strengthen the lining

      That butyrate fuels and strengthens your gut lining, the barrier that keeps digestion comfortable.*

      4

      Build a foundation that holds

      The result: a stronger gut foundation that also supports steady energy, blood sugar already within the normal range, and a healthy appetite, day to day.*

      What That Means For You

      More butyrate, a better-protected gut lining. The kind of difference you may feel as steadier digestion and everyday comfort. Butyrate now, and butyrate later.*

      Foundations take a little time.

      WEEK 1–3

      Settling in

      You may notice mild digestive changes as the strains settle in. This is usually temporary, a sign things are getting started.*

      MONTH 1–2

      Building the base

      Your gut is being supported and reinforced. Some people feel early benefits in this window. Results vary from person to person.*

      MONTH 3+

      A strong foundation

      With daily use, your gut runs steadier. A foundation for comfortable digestion and everyday wellness. Keep going to keep it strong.*

      What's inside your 5-in-1 formula.

      Nothing here by default. Each ingredient is clinically studied and was chosen because a million microbiomes pointed to it, then protected by patented DuoCap® delivery so it reaches the part of your gut where it works.*

      Advanced TriSynbiotic DuoCap capsule diagram

      OUTER CAPSULE

      BUTYRATE

      CoreBiome® Tributyrin

      Sends butyrate straight to the colon to fuel and strengthen your gut lining, and help support a healthy inflammatory response in the gut.*

      INNER CAPSULE

      POSTBIOTIC

      Akkermansia muciniphila

      Supports a stronger gut lining, and works in the small intestine too. Because it's a postbiotic, it's ready to work without surviving the trip.*

      PROBIOTIC

      Anaerobutyricum soehngenii CH106

      One of the most abundant butyrate producers in the small intestine. Turns fiber and sugars into beneficial butyrate, part of how a healthy gut supports a healthy appetite and blood sugar already within the normal range.*

      PROBIOTIC

      Bifidobacterium longum BB536

      Supports a balanced mix of good bacteria and a healthy immune system.*

      PROBIOTIC

      Lactiplantibacillus plantarum Lp815

      Releases GABA over time for added calm, better sleep, and stress support.*

      One capsule a day.That's it.

      1

      Simple to take

      Simple to take

      Just one capsule daily. An easy habit that supports your gut from the inside out.*

      Just one capsule daily. An easy habit that supports your gut from the inside out.*

      2

      Built to last

      Built to last

      Daily use keeps your gut steady and well-supported over time.*

      Daily use keeps your gut steady and well-supported over time.*

      3

      Protected delivery

      Protected delivery

      DuoCap® protects the ingredients and gets them to the right place at the right time.*

      DuoCap® protects the ingredients and gets them to the right place at the right time.*

      A strong gut foundation, one capsule a day.*

      A strong gut foundation, one capsule a day.*

      Questions, answered.

      Advanced TriSynbiotic product box
      Supplement capsule
      Green liquid formula

      Start on the foundation one million microbiomes helped build.

      Support the gut foundation everything else depends on,* with Advanced TriSynbiotic™. One capsule a day. And when you're ready to go deeper into your own biology, we'll be right here.

      Shop the Advanced TriSynbiotic™

      Advanced TriSynbiotic™

      [1] Marzorati M, Calatayud M, Rotsaert C, et al. Comparison of protection and release behavior of different capsule polymer combinations based on L. acidophilus survivability and function and caffeine release. Int J Pharm. 2021;607:120977. doi:10.1016/j.ijpharm.2021.120977

      These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The information Viome provides is for educational and informational use only and is not a substitute for professional medical advice. Available to US customers only, ages 14+.

      UP TO 46X MORE EFFECTIVE

      One capsule. Protected the whole way.

      It's just one capsule a day, engineered as a capsule-in-capsule. Patented DuoCap® technology delivers the ingredients up to 46X more effectively than conventional probiotic capsules [1], protecting them from stomach acid and releasing them in both the small and large intestine, where they actually work.

      1M+

      Microbiomes sequenced. The knowledge base behind the formula.

      5-in-1

      Three probiotics, a postbiotic, and butyrate delivered direct, in one capsule.

      46X

      More effective delivery than conventional probiotic capsules, to both the small and large intestine. [1]

      GLP-1 lifestyle

      Made to support a GLP-1 diet and lifestyle.*

      Postbiotic

      Akkermansia that's ready to work, no survival required.

      Butyrate

      Made by a butyrate-producing strain and delivered direct by CoreBiome®.*

      1 a day

      One simple capsule, diet-compatible.*